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Eduardo Sontag

University Distinguished Professor, Electrical and Computer Engineering
Jointly Appointed, Bioengineering
Affiliated Faculty, Chemical Engineering
326 ISEC
360 Huntington Avenue
Boston, MA 02115


  • PhD, University of Florida, 1977

Research & Scholarship Interests

Feedback control theory, systems biology, cancer, and biomedicine
Affiliated With

Department Research Areas

Honors & Awards

  • IEEE Control Systems Field Award
  • IFAC Fellow
  • AMS Fellow
  • SIAM Fellow
  • IEEE Fellow
  • Reid Prize in Applied Mathematics, SIAM

Selected Publications

  • E.V. Nikolaev, S.J. Rahi, E.D. Sontag, Chaos in Simple Periodically-Forced Biological Models, Biophysical Journal, 114, 2018, 1232-1240
  • T.H. Segall-Shapiro, E.D. Sontag, C.A. Voigt, Engineered Promoters Enable Constant Gene Expression at any Copy Number in Bacteria, Nature Biotechnology, 36, 2018, 352-358
  • J.K. Kim, E.D. Sontag, Reduction of Multiscale Stochastic Biochemical Reaction Networks Using Exact Moment Derivation, PLoS Computational Biology, 13(6), 2017, e1005571
  • E.D. Sontag, A Dynamical Model of Immune Responses to Antigen Presentation Predicts Different Regions of Tumor or Pathogen Elimination, Cell Systems, 4, 2017, 1-11
  • E.D. Sontag, Dynamic Compensation, Parameter Identifiability, and Equivariances, PLoS Computational Biology, 13, 2017, 1005447
  • S. Barish, M.F. Ochs, E.D. Sontag, J.L. Gevertz, Evaluating Optimal Therapy Robustness by Virtual Expansion of a Sample Population, with a Case Study in Cancer Immunotherapy, Proceedings of the National Academy of Sciences, 114, 2017, 6277-6286
  • E.V. Nikolaev, E.D. Sontag, Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory, PLoS Computational Biology, 12, 2016, e1004881

Related News

February 19, 2019

BioE University Distinguished Professor Eduardo Sontag's research has been published in Public Library of Science (PLOS) Computational Biology, a non-profit, peer-reviewed journal, entitled "Multi-modality in gene regulatory networks with slow promoter kinetics".

January 29, 2019

BioE University Distinguished Professor Eduardo Sontag's research entitled "Immunobiochemical Reconstruction of Influenza Lung Infection—Melanoma Skin Cancer Interactions" has been published in Frontiers in Immunology, a leading journal in its field.

July 17, 2018

ECE/BioE Professor Eduardo Sontag, in collaboration with Dr. Chris Voigt from MIT and Dr. Kate Adamala from the University of Minnesota-Twin Cities, was awarded a $1.5M three-year grant jointly funded from the National Science Foundation and Semiconductor Research Corporation for "Very Large-Scale Genetic Circuit Design Automation".