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Eduardo Sontag

University Distinguished Professor, Electrical and Computer Engineering
Interdisciplinary, Bioengineering
326 ISEC
360 Huntington Avenue
Boston, MA 02115


  • PhD, University of Florida, 1977

Research & Scholarship Interests

Feedback control theory, systems biology, cancer, and biomedicine
Affiliated With

Department Research Areas

Honors & Awards

  • IEEE Control Systems Field Award
  • IFAC Fellow
  • AMS Fellow
  • SIAM Fellow
  • IEEE Fellow
  • Reid Prize in Applied Mathematics, SIAM

Selected Publications

  • E.V. Nikolaev, S.J. Rahi, E.D. Sontag, Chaos in Simple Periodically-Forced Biological Models, Biophysical Journal, 114, 2018, 1232-1240
  • T.H. Segall-Shapiro, E.D. Sontag, C.A. Voigt, Engineered Promoters Enable Constant Gene Expression at any Copy Number in Bacteria, Nature Biotechnology, 36, 2018, 352-358
  • J.K. Kim, E.D. Sontag, Reduction of Multiscale Stochastic Biochemical Reaction Networks Using Exact Moment Derivation, PLoS Computational Biology, 13(6), 2017, e1005571
  • E.D. Sontag, A Dynamical Model of Immune Responses to Antigen Presentation Predicts Different Regions of Tumor or Pathogen Elimination, Cell Systems, 4, 2017, 1-11
  • E.D. Sontag, Dynamic Compensation, Parameter Identifiability, and Equivariances, PLoS Computational Biology, 13, 2017, 1005447
  • S. Barish, M.F. Ochs, E.D. Sontag, J.L. Gevertz, Evaluating Optimal Therapy Robustness by Virtual Expansion of a Sample Population, with a Case Study in Cancer Immunotherapy, Proceedings of the National Academy of Sciences, 114, 2017, 6277-6286
  • E.V. Nikolaev, E.D. Sontag, Quorum-Sensing Synchronization of Synthetic Toggle Switches: A Design Based on Monotone Dynamical Systems Theory, PLoS Computational Biology, 12, 2016, e1004881

Related News

July 17, 2018

ECE/BioE Professor Eduardo Sontag, in collaboration with Dr. Chris Voigt from MIT and Dr. Kate Adamala from the University of Minnesota-Twin Cities, was awarded a $1.5M three-year grant jointly funded from the National Science Foundation and Semiconductor Research Corporation for "Very Large-Scale Genetic Circuit Design Automation".

March 28, 2018

University Distinguished Professor Eduardo Sontag developed a new technique that would give researchers the ability to control the behavior of engineered cells.

January 8, 2018

Eduardo Sontag joins the Electrical and Computer Engineering department in January 2018 as a University Distinguished Professor with a joint appointment in Bioengineering.