This research is in collaboration with Prof. Gregory Kowalski in the Department of Mechanical and Industrial Engineering.
A confocal reflectance theta line-scanner is being developed for imaging nuclear, cellular and architectural detail in human tissues in vivo. Preliminary design and experimental results show lateral resolution of 1-5 mm and sectioning (axial resolution) of 2-5 mm is possible within living human skin; thus, nuclear and cellular detail has been imaged in epidermis in vivo. Experimental results are being verified with an analytic model and optical design analysis. An immediate clinical application will be intra-operative imaging of basal cell cancers to guide Mohs micrographic surgery for the precise excision of these cancers.
Optical Science Laboratory
This research project is part of the work at the Optical Science Laboratory of Chuck DiMarzio in the Department of Electrical and Computer Engineering at Northeastern University. For other projects see Optical Science Lab Research Page.